Last Publications (2008-2023)
Natural Killer T-like cells: immunobiology and role in disease
Almeida JS, Casanova JM, Santos-Rosa M, Tarazona R, Solana R, Rodrigues-Santos P.
Int J Med Sci 2023, 24(3), 2743.
doi: 10.3390/ijms24032743
Impact factor: 6.208 (2021) Q1 (Molecular Biology)
Genetic polymorphisms of Toll-like receptors in leprosy patients from Southern Brazil
Masin PS , Visentin HA, Elpidio LNS, Sell AM, Visentainer L, Lima Neto QA, Valentini Zacarias JM , Couceiro P, Santos Rosa M, Rodrigues-Santos P and Visentainer JEL
Front Genet 2022, 13, 952219.
Impact factor: 8.786 (2021) Q1 (Immunology)
Putative biomarkers in tears for diabetic retinopathy diagnosis and progression
Amorim M, Martins B, Caramelo FJ, Gonçalves C, Trindade G, Simão J, Barreto P, Marques I, Leal E, Carvalho E, Reis F, Ribeiro-Rodrigues T, Girao H, Rodrigues-Santos P, Farinha C, Ambrósio AF, Silva R, Fernandes R.
Front Med 2022, 9, 873483.
Impact factor: 5.091 (2021) Q1 (Medicine)
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation
Lobo ACS, Rodrigues-Santos P, Pereira D, Gonzalez J, Trêpa JCD, Sousa DL, Lourenço JR, Coelho MF, Almeida LP, Saraiva da Cunha J, Arnaut LG.
Photochem. Photobiol. Sci 2022, 21(3).
doi: 10.1007/s43630
Impact factor: 3.982 (2021) Q2 (Medicine/miscellaneous)
Dynamics of soluble factors and double-negative T cells associated with response to renal denervation in resistant hypertension patients
Delgado-Silva J†, Rodrigues-Santos P†, Almeida JS, Santos-Rosa M, Gonçalves L.
† These authors have contributed equally to this work and share co-first authorship.
J Pers Med 2022, 1574452
doi: 10.3390/jpm1574452
Impact factor: 4.945 (2020) Q1 (Medicine/miscellaneous)
Tumor-infiltrating lymphocytes and cancer markers in osteosarcoma: influence on patient survival
Casanova JM, Almeida JS, Reith J, Sousa LM, Fonseca R, Freitas-Tavares P, Santos-Rosa M, Rodrigues-Santos P.
Cancers 2021, 13(23), 6075.
doi: 10.3390/cancers13236075
Impact factor: 6.639 (2020) Q1 (Oncology)
Fortes-Andrade T, Almeida JS, Sousa LM, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
The role of Natural Killer cells in Soft Tissue Sarcoma: prospects for immunotherapy
Cancers 2021, 13(15), 3865.
doi: 10.3390/cancers13153865
Impact factor: 6.639 (2020) Q1 (Oncology)
Sousa LM, Almeida JS, Fortes-Andrade T, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
Tumor and peripheral immune status in Soft Tissue Sarcoma: implications for immunotherapy
Cancers 2021, 13(15), 3885.
doi: 10.3390/cancers13153885
Impact factor: 6.639 (2020) Q1 (Oncology)
Mendes J, Rodrigues‑Santos P, Areia AL, Almeida JS, Alves V, Santos-Rosa M, Mota-Pinto A.
Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implications in preterm birth
BMC Immunology 2021, 22:28.
doi: 10.1186/s12865-021-00423-x
Impact factor: 3.615 (2020) Q2 (Immunology)
Cunha Pereira T, Rodrigues‑Santos P, Almeida JS, Rêgo Salgueiro F, Monteiro AR, Macedo F, Félix Soares R, Domingues I, Jacinto P, Sousa G
Immunotherapy and predictive immunologic profile: the tip of the iceberg
Medical Oncology 2021, 38:51.
doi: 10.1007/s12032-021-01497-8
Impact factor: 3.064 (2020) Q2 (Oncology)
Campeão M, Fernandes L, Pita IR, Lemos C, Ali SF, Carvalho F, Rodrigues-Santos P, Fontes-Ribeiro CA, Soares E, Viana SD, Pereira FC.
Acute MDPV binge paradigm on mice emotional behavior and glial signature
Pharmaceuticals 2021, 14(3), 271.
Impact factor: 5.863 (2020) Q1 (Pharmaceutical Sciences)
Mendes JF, Areia AL, Rodrigues-Santos P, Santos-Rosa M, Mota-Pinto A.
Innate Lymphoid cells In Human Pregnancy.
Front Immunol 2020. doi: 10.3389/fimmu.2020.551707
Impact factor: 7.561 (2020) Q1 (Immunology)
Delgado-Silva J, Almeida J, Rodrigues-Santos P, Santos-Rosa M, Gonçalves L.
Activated double-negative T cells (CD3+CD4-CD8-HLA-DR+) define response to renal denervation for resistant hypertension.
Clin Immunol 2020, 218:108521.
Impact factor: 3.969 (2020) Q2 (Immunology)
Lobo ACS, Gomes-da-Silva LC, Rodrigues-Santos P, Cabrita A, Santos-Rosa M, Arnaut LG.
Immune Responses After Vascular Photodynamic Therapy with Redaporfin.
J Clin Med 2020, 9(1):104.
Impact factor: 4241 (2020) Q1 (Medicine, General & Internal)
Almeida JS, Couceiro P, López Sejas N, Alves V, Ruzičková L, Tarazona R, Solana R, Freitas-Tavares P, Santos Rosa M, Rodrigues-Santos P.
NKT-like (CD3+CD56+) cells in Chronic Myeloid Leukaemia patients treated with Tyrosine Kinase Inhibitors.
Front Immunol 2019. doi: 10.3389/fimmu.2019.02493
Impact factor: 5.085 (2019) Q1 (Immunology)
Rodrigues-Santos P, López Sejas N, Almeida JS, Ruzičková L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R, Santos Rosa M.
Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Front Immunol 2018. doi: 10.3389/fimmu.2018.02587
Impact factor: 5.511 (2017) Q1 (Immunology)
Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease
Mol Ther. 2018 Sep 5;26(9):2131-2151.
Impact factor: 6.688 (2017) Q1 (Molecular Medicine, Molecular Biology, Genetics, Drug Discovery, Pharmacology)
Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Caetano-Oliveira R, Gomes MA, Abrantes AM, Tavares-Silva E, Oliveira MC, Laranjo M, Queirós DB, Casalta-Lopes J, Pires S, Carvalho L, Gouveia R, Rodrigues-Santos P, Priolli DG, Tralhão JG, Botelho MF.
Pathophysiology. 2018 Mar 13. pii: S0928-4680(17)30152-9.
Impact factor: 2.910 (2017) Q1 (Pathology and Forensic Medicine, Physiology/medical)
Viana S, Pita I, Lemos C, Rial D, Couceiro P, Rodrigues-Santos P, Caramelo F, Carvalho F, Ali SF, Prediger R, Fontes Ribeiro C, Pereira F.
The effects of physical exercise on non-motor symptoms and on neuroimmune RAGE-network in experimental parkinsonism.
J Applied Physiol 2017, 123(1):161-171.
Impact factor: 3.256 (2017) Q1 (Physiology/medical, Physiology, Medicine/miscellaneous, Sports Science)
Ferreira-Teixeira M, Paiva-Oliveira D, Parada B, Alves V, Sousa V, Chijioke O, Münz C, Reis F, Gomes C, Rodrigues-Santos P.
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.
BMC Medicine 2016 14(1):163.
Impact factor: 7.901 (2016) Q1 (Medicine/miscellaneous)
Viana SD, Valero J, Rodrigues-Santos P, Couceiro P, Silva AM, Carvalho F, Ali SF, Fontes-Ribeiro CA, Pereira FC.
Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease.
J Neurochem 2016;138(4):598-609.
Mendes F, Domingues C, Rodrigues-Santos P, Abrantes AM, Gonçalves AC, Estrela J, Encarnação J, Pires AS, Laranjo M, Alves V, Teixo RJ; Sarmento-Ribeiro AB, Botelho MF, Santos-Rosa M.
The role of immune system exhaustion on cancer cells escape and anti-tumor immune induction after irradiation.
Biochim Biophys Acta, 2016; 1865(2):168-175.
Monophosphoryl Lipid-A: A Promising Tool for Alzheimer's Disease Toll.
Rego Â, Viana SD, Ribeiro CA, Rodrigues-Santos P, Pereira FC.
J Alzheimers Dis 2016;52(4):1189-202.
Mazini PS, Alves HV, Reis PG, Lopes AP, Sell AM, Santos-Rosa M, Visentainer JEL and Rodrigues-Santos P
Gene Association with Leprosy: A Review of Published Data.
Front Immunol 2016, 6:658.
Impact factor: 6.429 (2016) Q1 (Immunology)
Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Santos-Rosa M, Moura P, Mota-Pinto A.
Can membrane progesterone receptor alpha on T regulatory cells explain the ensuing human labour?
J Reprod Immunol 2016, 113: 22–26.
Ferreira-Teixeira M, Parada B, Rodrigues-Santos P, Alves V, Ramalho JS, Caramelo F, Sousa V, Reis F, Gomes CM.
Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors.
Oncotarget. 2015; 6(34):36185-201.
Rodrigues-Santos P, Santos P, Tralhão JG, Serôdio M, Botelho MF, Pais ML, Castro Sousa F.
Gene expression profile of circulating tumor cells from primary or liver metastatic colorectal cancer.
Hepato-Gastroenterology 2016 (in press)
Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Santos Rosa M, Moura P, Mota-Pinto A.
Does progesterone administration in preterm labor influence Treg cells?
J Perinat Med 2016; (6):605-612.
Fonseca NA, Rodrigues AS, Rodrigues-Santos P, Alves V, Gregório AC, Valério-Fernandes A, Gomes-da-Silva LC, Santos Rosa M, Moura V, Ramalho-Santos J, Simões S, Moreira JN.
Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination.
Biomaterials 2015, 69:76–88.
Alves R, Fonseca AR, Gonçalves AC, Ferreira-Teixeira M, Lima J, Abrantes AM, Alves V, Rodrigues-Santos P, Jorge L, Matoso E, Carreira IM, Botelho MF, Sarmento-Ribeiro AB.
Drug Transporters play a key role in the complex process of Imatinib Resistance in vitro.
Leuk Res 2015;39(3):355-60.
Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Moura P, Mota Pinto A.
Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy.
BJOG 2015. DOI: 10.1111/1471-0528.13294.
Sereno J, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Alves R, Fernandes J, Santos-Silva A, Carvalho E, Teixeira F, Reis F.
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.
Int J Mol Sci. 2014 May 20;15(5):8979-97.
Sereno J, Nunes S, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Fernandes J, Santos-Silva A, Teixeira F, Reis F.
Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat – focus on serum, urine, gene and protein renal expression biomarkers.
BioMed Res Int 2014; 576929.
Coirada F, Couceiro P, Mazini P, Gomes-Silva D, Alves V, Visentainer JEL, Santos-Rosa M, Freitas-Tavares P, Rodrigues-Santos P.
CD137 (4-1BB) as therapeutic target in Chronic Myeloid Leukemia: immunophenotyping, gene expression profile and functional studies in lymphocyte subsets on patients treated with imatinib mesylate.
Rev Port Pneumol 2014, 20:1-7.
Couceiro P, Soverini S, Gomes-Silva D, Freitas-Tavares P, Rodrigues-Santos P.
Screening of ABL kinase domain mutations in Chronic Myeloid Leukemia using Next-Generation Sequencing: impact in monitoring response to tyrosine kinase inhibitor therapy.
Rev Port Pneumol 2014, 20:8-32.
Marques C, Mega AC, Gonçalves A, Rodrigues-Santos P, Teixeira-Lemos E, Teixeira F, Fontes-Ribeiro C, Reis F, Fernandes R.
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals
Mediators Inflamm 2014, 538737.
Mega C, Vala H, Rodrigues-Santos P, Oliveira J, Teixeira F, Rosa Fernandes, Reis F, Teixeira-Lemos E.
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties.
Diabetology & Metabolic Syndrome 2014, 6:42.
Bustin S, Benes V, Garson J, Abreu M, Ferreira-Teixeira M, Rodrigues-Santos P et al.
The need for transparency and good practices in the qPCR literature.
Nature Methods 2013; 10(11):1063-1067.
Abreu MT, Carvalheiro H, Rodrigues-Sousa T, Domingos A, Segorbe-Luís A, Souto-Carneiro MM.Rodrigues-Santos P.
Alterations in the peripheral blood B cell subpopulations of multidrug resistant tuberculosis patients.
Clin Exp Med 2013, DOI 10.1007/s10238-013-0258-1.
Sereno J, Parada B, Rodrigues-Santos P, Lopes PC, Carvalho E, Vala H, Teixeira-Lemos E, Alves R, Figueiredo A, Mota A, Teixeira F, Reis F.
Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.
Transplant Proc. 2013;45(3):1149-56.
Silva D, Couceiro P, Ferreira-Teixeira M, Tavares P, Sá H, Rodrigues-Santos P.
IL-2, IL-12 and IL-15 prevent reactive oxygen species accumulation on Natural Killer cells from Chronic Myeloid Leukaemia patients following interferon-alpha, imatinib and dasatinib therapy
Rev Port Pneumol. 2013;19:17.
Teixeira-Lemos E, Teixeira HM, Piloto N, Teixeira M, Parada B, Rodrigues-Santos P, Carvalho L, Alves R, Costa E, Belo L, Santos-Silva A, Teixeira F, Reis R.
Cardiometabolic Injury Due to Recombinant Human Erythropoietin Doping for Improvement of Sports Performance: Chronic (Training) versus Acute (Extenuating) Aerobic Exercise.
In: Bastos JH, Silva AC, editors. Athlete Performance and Injuries: Nova Science Pub Inc; 2012. p. 99-121.
Couceiro P, Ferreira Teixeira M, Freitas Tavares P, Rodrigues Santos P.
Screening of ABL kinase domain mutations using high-resolution melting in Chronic Myeloid Leukaemia: impact in the response to treatment with tyrosine kinase inhibitors
Rev Port Pneumol. 2013;19:17.
Barbosa M, Lopes A, Mota C, Mota MC, Oliveira J, Rodrigues-Santos P, De Bonis P, Bisceglia L, Cardoso ML.
Clinical, Biochemical and Molecular characterization of Cystinuria in a cohort of 12 patients
Clin Genet. 2012 Jan;81(1):47-55.
M Reis Silva, C Oliveira, P Rodrigues-Santos, L Carvalho
Genotypes of Helicobacter pylori in Gastric Cancer and Chronic Gastritis
GE J Port Gastroenterol 2011; 5: 218-225.
M Teixeira, P Rodrigues-Santos, P Garrido, E Costa, B Parada, J Sereno, R Alves, L Belo, F Teixeira, A Santos-Silva, F Reis
Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat
J Pharm Bioallied Sci. 2012 Jan;4(1):76-83.
I Velada, F Capela-Silva, F Reis, E Pires, C Egas, P Rodrigues-Santos, MT Barros
Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia
J Comp Pathol. 2011 Aug-Oct;145(2-3):174-86.
B Parada, F Reis, A Figueiredo, P Nunes, E Teixeira-Lemos, P Garrido, J Sereno, R Pinto, M FX Cunha, P Neto, P Santos, I Velada, A Mota, F Teixeira.
Inhibition of Bladder Tumour Growth by Sirolimus in an Experimental Carcinogenesis Model.
Br J Urology 2011, 107:135-143.
J Sereno, B Parada, F Reis, F Xavier-Cunha, E Teixeira-Lemos, PGarrido, R Pinto, P Rocha-Pereira, P Neto, P Rodrigues-Santos, S Nunes, A Mota,A Figueiredo, F Teixeira
Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model
Mediators of Inflamm 2010: Article ID 380937.
B Raposo, P Rodrigues-Santos, H Carvalheiro, A Agua-Doce, L Carvalho, JA Pereira da Silva, L Graça, M Souto-Carneiro
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis
Arthritis Rheum 2010, 62(10): 2953-2962.
A Henriques, L Inês, M Couto, S Pedreiro, C Santos; M Magalhães, P Santos, I Velada, A Almeida, T Carvalheiro, P Laranjeira, J Morgado, ML Pais, JP Silva, A Paiva.
Frequency and Functional Activity of Th17, Tc17 and other T cell subsets in Systemic Lupus Erythematosus.
Cell Immunol 2010, 264(1):97-103.
JA Hollenbach, A Meenagh, C Sleator, C Alaez, M Bengoche, A Canossi, G Contreras, L Creary, I Evseeva, C Gorodezky, R-A Hardie, T Hemming Karlsen, B Lie, M Luo, M Martinetti, C Navarette, D CM de Oliveira, G Ozzella, A Pasi, E Pavlova, S Pinto, LC Porto, P Santos, A Slavcev, D Srinak, S Tavoularis, S Tonks, E Trachtenberg, S Vejbaesya & D Middleton.
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.
Tissue Antigens 2010, 76(1):9-17.
AM Teixeira, P Garrido, P Santos, R Alves R, Parada B, Costa E, Almeida A, Teixeira-Lemos E, Sereno J, Pinto R, Belo L, Santos-Silva A, Teixeira F, Reis F.
Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure.
Ren Fail. 2010;32(9):1073-80.
L Geraldes, J Morgado, A Almeida, A Todo-Bom, P Santos, A Paiva, C Chieira, ML Pais
Different patterns of gene expression of CD4+/CD25++/CD127low Regulatory T-cells HLA-DR+
or HLA-DR- in allergy
J Investig Allergol Clin Immunol. 2010;20(3):201-9.
L Ferreira, E Teixeira de Lemos, AF Pinto, B Parada, R Pinto, P Santos, C Mega, H Vala, Garrido P, Sereno J, Melo A, Teixeira F, Reis F
Sitagliptin treatment corrects the cardiometabolic dysfunction in an animal model of type 2 diabetes (ZDF rat)
Mediators Inflamm 2010 (doi:10.1155/2010/592760)
A Almeida, P Santos, A Cabrita, R Alves
The sex influence in chronic kidney disease. Teachings from a genomic approach to fibrosis in experimental obstructive nephropathy
Port J Nephrol Hypert 2010; 24(3).
M Silva, D Azenha, C Pereira, A Almeida, S Balseiro, AM Sampaio, P Santos, L Carvalho.
Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDNK2A (P16INK4A), PTGS2 (COX2) and EGFR genes through methylation.
Acta Med Port. 2010; 23(1):005-014.
P Garrido, E Costa, E Texeira-Lemos, B Parada, M Teixeira, P Santos, N Piloto, P Sereno, R Alves, R Pinto, P Rocha-Pereira, A Figueiredo, S Nunes, AMP Romão, L Carvalho, P Couceiro, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological, biochemical and cardiovascular characterization of a rat model of moderate chronic kidney disease.
Bol Soc Port Hemorreol Microcir 2010, 25(2): 9-22.
N Piloto, HM Teixeira, P Garrido, E Teixeira-Lemos, M Teixeira, B Parada, J Sereno, R Pinto, R Alves, P Santos, AM Romão, S Nunes, P Neto, L Carvalho, P Couceiro, F Xavier, P Rocha-Pereira, E Costa, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping.
Bol Soc Port Hemorreol Microcir 2010, 25(1): 11-22.
C Simões, A Almeida, P Santos, A Paiva.
CCR7 e CXCR4 expression and cyclin D1 mRNA expression in mantle cell lymphoma and B cell chronic lymphocytic leukemia.
Rev Port Cienc Biomed 2010; V(5): 10-15.
C Camacho, L Carvalho, L Pereira, E Maia, M J Araújo, R Cortes, P Santos.
MBL in chronic infection by hepatitis B virus: structural and promoter genetic polymorphisms and its correlations with plasmatic levels of oligomeric forms.
Rev Port Cienc Biomed 2010; V(5): 22-27.
L Vicente, AP Rodrigues, AP Galante, E Silva, F Simões, I Marques, H Gonçalves, P Santos
Searching for Cytomegalovirus DNA after leukofiltration of blood transfusion units.
Rev Port Cienc Biomed 2010; V(5): 34-37.
A Almeida, R Alves, P Santos
Experimental models of chronic renal disease by obstruction: functional genomics point of view
Rev Port Cienc Biomed 2009; IV(4): 24-31.
R Leite, R Mareco, C Faustino, P Santos
HLA-B*27: high-resolution molecular information and immunopathology
Rev Port Cienc Biomed 2009; IV(4): 40-44.
AI Duarte, P Santos, CR Oliveira, MS Santos, AC Rego.
Insulinneuroprotection against oxidative stress is mediated by Akt and GSK-3βsignalling pathways and changes in protein expression.
Biochem Biophys Acta - Mol Cell Res 2008; 1793(6):994-1002.
MR Silva, A Sampaio, A Almeida, S Balseiro, P Santos, L Carvalho
Identification of IL1B, IL1RN and TNFA gene polymorphisms in chronic gastritis associated toHelicobacter pylori infection and gastric carcinoma.
GE - J Port Gastroenterol 2008;15:8-15.
A Sampaio, P Santos
Factores genéticos do Helicobacter pylori e do hospedeiro na carcinogenese gástrica
Rev Port Cienc Biomed 2008; III(3): 72-78.
Almeida JS, Casanova JM, Santos-Rosa M, Tarazona R, Solana R, Rodrigues-Santos P.
Int J Med Sci 2023, 24(3), 2743.
doi: 10.3390/ijms24032743
Impact factor: 6.208 (2021) Q1 (Molecular Biology)
Genetic polymorphisms of Toll-like receptors in leprosy patients from Southern Brazil
Masin PS , Visentin HA, Elpidio LNS, Sell AM, Visentainer L, Lima Neto QA, Valentini Zacarias JM , Couceiro P, Santos Rosa M, Rodrigues-Santos P and Visentainer JEL
Front Genet 2022, 13, 952219.
Impact factor: 8.786 (2021) Q1 (Immunology)
Putative biomarkers in tears for diabetic retinopathy diagnosis and progression
Amorim M, Martins B, Caramelo FJ, Gonçalves C, Trindade G, Simão J, Barreto P, Marques I, Leal E, Carvalho E, Reis F, Ribeiro-Rodrigues T, Girao H, Rodrigues-Santos P, Farinha C, Ambrósio AF, Silva R, Fernandes R.
Front Med 2022, 9, 873483.
Impact factor: 5.091 (2021) Q1 (Medicine)
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation
Lobo ACS, Rodrigues-Santos P, Pereira D, Gonzalez J, Trêpa JCD, Sousa DL, Lourenço JR, Coelho MF, Almeida LP, Saraiva da Cunha J, Arnaut LG.
Photochem. Photobiol. Sci 2022, 21(3).
doi: 10.1007/s43630
Impact factor: 3.982 (2021) Q2 (Medicine/miscellaneous)
Dynamics of soluble factors and double-negative T cells associated with response to renal denervation in resistant hypertension patients
Delgado-Silva J†, Rodrigues-Santos P†, Almeida JS, Santos-Rosa M, Gonçalves L.
† These authors have contributed equally to this work and share co-first authorship.
J Pers Med 2022, 1574452
doi: 10.3390/jpm1574452
Impact factor: 4.945 (2020) Q1 (Medicine/miscellaneous)
Tumor-infiltrating lymphocytes and cancer markers in osteosarcoma: influence on patient survival
Casanova JM, Almeida JS, Reith J, Sousa LM, Fonseca R, Freitas-Tavares P, Santos-Rosa M, Rodrigues-Santos P.
Cancers 2021, 13(23), 6075.
doi: 10.3390/cancers13236075
Impact factor: 6.639 (2020) Q1 (Oncology)
Fortes-Andrade T, Almeida JS, Sousa LM, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
The role of Natural Killer cells in Soft Tissue Sarcoma: prospects for immunotherapy
Cancers 2021, 13(15), 3865.
doi: 10.3390/cancers13153865
Impact factor: 6.639 (2020) Q1 (Oncology)
Sousa LM, Almeida JS, Fortes-Andrade T, Santos-Rosa M, Freitas-Tavares P, Casanova JM, Rodrigues‑Santos P.
Tumor and peripheral immune status in Soft Tissue Sarcoma: implications for immunotherapy
Cancers 2021, 13(15), 3885.
doi: 10.3390/cancers13153885
Impact factor: 6.639 (2020) Q1 (Oncology)
Mendes J, Rodrigues‑Santos P, Areia AL, Almeida JS, Alves V, Santos-Rosa M, Mota-Pinto A.
Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implications in preterm birth
BMC Immunology 2021, 22:28.
doi: 10.1186/s12865-021-00423-x
Impact factor: 3.615 (2020) Q2 (Immunology)
Cunha Pereira T, Rodrigues‑Santos P, Almeida JS, Rêgo Salgueiro F, Monteiro AR, Macedo F, Félix Soares R, Domingues I, Jacinto P, Sousa G
Immunotherapy and predictive immunologic profile: the tip of the iceberg
Medical Oncology 2021, 38:51.
doi: 10.1007/s12032-021-01497-8
Impact factor: 3.064 (2020) Q2 (Oncology)
Campeão M, Fernandes L, Pita IR, Lemos C, Ali SF, Carvalho F, Rodrigues-Santos P, Fontes-Ribeiro CA, Soares E, Viana SD, Pereira FC.
Acute MDPV binge paradigm on mice emotional behavior and glial signature
Pharmaceuticals 2021, 14(3), 271.
Impact factor: 5.863 (2020) Q1 (Pharmaceutical Sciences)
Mendes JF, Areia AL, Rodrigues-Santos P, Santos-Rosa M, Mota-Pinto A.
Innate Lymphoid cells In Human Pregnancy.
Front Immunol 2020. doi: 10.3389/fimmu.2020.551707
Impact factor: 7.561 (2020) Q1 (Immunology)
Delgado-Silva J, Almeida J, Rodrigues-Santos P, Santos-Rosa M, Gonçalves L.
Activated double-negative T cells (CD3+CD4-CD8-HLA-DR+) define response to renal denervation for resistant hypertension.
Clin Immunol 2020, 218:108521.
Impact factor: 3.969 (2020) Q2 (Immunology)
Lobo ACS, Gomes-da-Silva LC, Rodrigues-Santos P, Cabrita A, Santos-Rosa M, Arnaut LG.
Immune Responses After Vascular Photodynamic Therapy with Redaporfin.
J Clin Med 2020, 9(1):104.
Impact factor: 4241 (2020) Q1 (Medicine, General & Internal)
Almeida JS, Couceiro P, López Sejas N, Alves V, Ruzičková L, Tarazona R, Solana R, Freitas-Tavares P, Santos Rosa M, Rodrigues-Santos P.
NKT-like (CD3+CD56+) cells in Chronic Myeloid Leukaemia patients treated with Tyrosine Kinase Inhibitors.
Front Immunol 2019. doi: 10.3389/fimmu.2019.02493
Impact factor: 5.085 (2019) Q1 (Immunology)
Rodrigues-Santos P, López Sejas N, Almeida JS, Ruzičková L, Couceiro P, Alves V, Campos C, Alonso C, Tarazona R, Freitas-Tavares P, Solana R, Santos Rosa M.
Effect of age on NK cell compartment in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Front Immunol 2018. doi: 10.3389/fimmu.2018.02587
Impact factor: 5.511 (2017) Q1 (Immunology)
Oliveira Miranda C, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Barros I, Alves J, Sereno J, Petrella LI, Castelhano J, Paiva VH, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M, Pereira de Almeida L.
Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease
Mol Ther. 2018 Sep 5;26(9):2131-2151.
Impact factor: 6.688 (2017) Q1 (Molecular Medicine, Molecular Biology, Genetics, Drug Discovery, Pharmacology)
Revisiting colorectal cancer animal model - An improved metastatic model for distal rectosigmoid colon carcinoma.
Caetano-Oliveira R, Gomes MA, Abrantes AM, Tavares-Silva E, Oliveira MC, Laranjo M, Queirós DB, Casalta-Lopes J, Pires S, Carvalho L, Gouveia R, Rodrigues-Santos P, Priolli DG, Tralhão JG, Botelho MF.
Pathophysiology. 2018 Mar 13. pii: S0928-4680(17)30152-9.
Impact factor: 2.910 (2017) Q1 (Pathology and Forensic Medicine, Physiology/medical)
Viana S, Pita I, Lemos C, Rial D, Couceiro P, Rodrigues-Santos P, Caramelo F, Carvalho F, Ali SF, Prediger R, Fontes Ribeiro C, Pereira F.
The effects of physical exercise on non-motor symptoms and on neuroimmune RAGE-network in experimental parkinsonism.
J Applied Physiol 2017, 123(1):161-171.
Impact factor: 3.256 (2017) Q1 (Physiology/medical, Physiology, Medicine/miscellaneous, Sports Science)
Ferreira-Teixeira M, Paiva-Oliveira D, Parada B, Alves V, Sousa V, Chijioke O, Münz C, Reis F, Gomes C, Rodrigues-Santos P.
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.
BMC Medicine 2016 14(1):163.
Impact factor: 7.901 (2016) Q1 (Medicine/miscellaneous)
Viana SD, Valero J, Rodrigues-Santos P, Couceiro P, Silva AM, Carvalho F, Ali SF, Fontes-Ribeiro CA, Pereira FC.
Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease.
J Neurochem 2016;138(4):598-609.
Mendes F, Domingues C, Rodrigues-Santos P, Abrantes AM, Gonçalves AC, Estrela J, Encarnação J, Pires AS, Laranjo M, Alves V, Teixo RJ; Sarmento-Ribeiro AB, Botelho MF, Santos-Rosa M.
The role of immune system exhaustion on cancer cells escape and anti-tumor immune induction after irradiation.
Biochim Biophys Acta, 2016; 1865(2):168-175.
Monophosphoryl Lipid-A: A Promising Tool for Alzheimer's Disease Toll.
Rego Â, Viana SD, Ribeiro CA, Rodrigues-Santos P, Pereira FC.
J Alzheimers Dis 2016;52(4):1189-202.
Mazini PS, Alves HV, Reis PG, Lopes AP, Sell AM, Santos-Rosa M, Visentainer JEL and Rodrigues-Santos P
Gene Association with Leprosy: A Review of Published Data.
Front Immunol 2016, 6:658.
Impact factor: 6.429 (2016) Q1 (Immunology)
Areia A, Vale-Pereira S, Alves V, Rodrigues-Santos P, Santos-Rosa M, Moura P, Mota-Pinto A.
Can membrane progesterone receptor alpha on T regulatory cells explain the ensuing human labour?
J Reprod Immunol 2016, 113: 22–26.
Ferreira-Teixeira M, Parada B, Rodrigues-Santos P, Alves V, Ramalho JS, Caramelo F, Sousa V, Reis F, Gomes CM.
Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors.
Oncotarget. 2015; 6(34):36185-201.
Rodrigues-Santos P, Santos P, Tralhão JG, Serôdio M, Botelho MF, Pais ML, Castro Sousa F.
Gene expression profile of circulating tumor cells from primary or liver metastatic colorectal cancer.
Hepato-Gastroenterology 2016 (in press)
Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Santos Rosa M, Moura P, Mota-Pinto A.
Does progesterone administration in preterm labor influence Treg cells?
J Perinat Med 2016; (6):605-612.
Fonseca NA, Rodrigues AS, Rodrigues-Santos P, Alves V, Gregório AC, Valério-Fernandes A, Gomes-da-Silva LC, Santos Rosa M, Moura V, Ramalho-Santos J, Simões S, Moreira JN.
Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination.
Biomaterials 2015, 69:76–88.
Alves R, Fonseca AR, Gonçalves AC, Ferreira-Teixeira M, Lima J, Abrantes AM, Alves V, Rodrigues-Santos P, Jorge L, Matoso E, Carreira IM, Botelho MF, Sarmento-Ribeiro AB.
Drug Transporters play a key role in the complex process of Imatinib Resistance in vitro.
Leuk Res 2015;39(3):355-60.
Areia AL, Vale-Pereira S, Vaz-Ambrósio A, Alves V, Rodrigues-Santos P, Moura P, Mota Pinto A.
Membrane progesterone receptors in human regulatory T cells: a reality in pregnancy.
BJOG 2015. DOI: 10.1111/1471-0528.13294.
Sereno J, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Alves R, Fernandes J, Santos-Silva A, Carvalho E, Teixeira F, Reis F.
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.
Int J Mol Sci. 2014 May 20;15(5):8979-97.
Sereno J, Nunes S, Rodrigues-Santos P, Vala H, Rocha-Pereira P, Fernandes J, Santos-Silva A, Teixeira F, Reis F.
Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat – focus on serum, urine, gene and protein renal expression biomarkers.
BioMed Res Int 2014; 576929.
Coirada F, Couceiro P, Mazini P, Gomes-Silva D, Alves V, Visentainer JEL, Santos-Rosa M, Freitas-Tavares P, Rodrigues-Santos P.
CD137 (4-1BB) as therapeutic target in Chronic Myeloid Leukemia: immunophenotyping, gene expression profile and functional studies in lymphocyte subsets on patients treated with imatinib mesylate.
Rev Port Pneumol 2014, 20:1-7.
Couceiro P, Soverini S, Gomes-Silva D, Freitas-Tavares P, Rodrigues-Santos P.
Screening of ABL kinase domain mutations in Chronic Myeloid Leukemia using Next-Generation Sequencing: impact in monitoring response to tyrosine kinase inhibitor therapy.
Rev Port Pneumol 2014, 20:8-32.
Marques C, Mega AC, Gonçalves A, Rodrigues-Santos P, Teixeira-Lemos E, Teixeira F, Fontes-Ribeiro C, Reis F, Fernandes R.
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals
Mediators Inflamm 2014, 538737.
Mega C, Vala H, Rodrigues-Santos P, Oliveira J, Teixeira F, Rosa Fernandes, Reis F, Teixeira-Lemos E.
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties.
Diabetology & Metabolic Syndrome 2014, 6:42.
Bustin S, Benes V, Garson J, Abreu M, Ferreira-Teixeira M, Rodrigues-Santos P et al.
The need for transparency and good practices in the qPCR literature.
Nature Methods 2013; 10(11):1063-1067.
Abreu MT, Carvalheiro H, Rodrigues-Sousa T, Domingos A, Segorbe-Luís A, Souto-Carneiro MM.Rodrigues-Santos P.
Alterations in the peripheral blood B cell subpopulations of multidrug resistant tuberculosis patients.
Clin Exp Med 2013, DOI 10.1007/s10238-013-0258-1.
Sereno J, Parada B, Rodrigues-Santos P, Lopes PC, Carvalho E, Vala H, Teixeira-Lemos E, Alves R, Figueiredo A, Mota A, Teixeira F, Reis F.
Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.
Transplant Proc. 2013;45(3):1149-56.
Silva D, Couceiro P, Ferreira-Teixeira M, Tavares P, Sá H, Rodrigues-Santos P.
IL-2, IL-12 and IL-15 prevent reactive oxygen species accumulation on Natural Killer cells from Chronic Myeloid Leukaemia patients following interferon-alpha, imatinib and dasatinib therapy
Rev Port Pneumol. 2013;19:17.
Teixeira-Lemos E, Teixeira HM, Piloto N, Teixeira M, Parada B, Rodrigues-Santos P, Carvalho L, Alves R, Costa E, Belo L, Santos-Silva A, Teixeira F, Reis R.
Cardiometabolic Injury Due to Recombinant Human Erythropoietin Doping for Improvement of Sports Performance: Chronic (Training) versus Acute (Extenuating) Aerobic Exercise.
In: Bastos JH, Silva AC, editors. Athlete Performance and Injuries: Nova Science Pub Inc; 2012. p. 99-121.
Couceiro P, Ferreira Teixeira M, Freitas Tavares P, Rodrigues Santos P.
Screening of ABL kinase domain mutations using high-resolution melting in Chronic Myeloid Leukaemia: impact in the response to treatment with tyrosine kinase inhibitors
Rev Port Pneumol. 2013;19:17.
Barbosa M, Lopes A, Mota C, Mota MC, Oliveira J, Rodrigues-Santos P, De Bonis P, Bisceglia L, Cardoso ML.
Clinical, Biochemical and Molecular characterization of Cystinuria in a cohort of 12 patients
Clin Genet. 2012 Jan;81(1):47-55.
M Reis Silva, C Oliveira, P Rodrigues-Santos, L Carvalho
Genotypes of Helicobacter pylori in Gastric Cancer and Chronic Gastritis
GE J Port Gastroenterol 2011; 5: 218-225.
M Teixeira, P Rodrigues-Santos, P Garrido, E Costa, B Parada, J Sereno, R Alves, L Belo, F Teixeira, A Santos-Silva, F Reis
Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat
J Pharm Bioallied Sci. 2012 Jan;4(1):76-83.
I Velada, F Capela-Silva, F Reis, E Pires, C Egas, P Rodrigues-Santos, MT Barros
Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia
J Comp Pathol. 2011 Aug-Oct;145(2-3):174-86.
B Parada, F Reis, A Figueiredo, P Nunes, E Teixeira-Lemos, P Garrido, J Sereno, R Pinto, M FX Cunha, P Neto, P Santos, I Velada, A Mota, F Teixeira.
Inhibition of Bladder Tumour Growth by Sirolimus in an Experimental Carcinogenesis Model.
Br J Urology 2011, 107:135-143.
J Sereno, B Parada, F Reis, F Xavier-Cunha, E Teixeira-Lemos, PGarrido, R Pinto, P Rocha-Pereira, P Neto, P Rodrigues-Santos, S Nunes, A Mota,A Figueiredo, F Teixeira
Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model
Mediators of Inflamm 2010: Article ID 380937.
B Raposo, P Rodrigues-Santos, H Carvalheiro, A Agua-Doce, L Carvalho, JA Pereira da Silva, L Graça, M Souto-Carneiro
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis
Arthritis Rheum 2010, 62(10): 2953-2962.
A Henriques, L Inês, M Couto, S Pedreiro, C Santos; M Magalhães, P Santos, I Velada, A Almeida, T Carvalheiro, P Laranjeira, J Morgado, ML Pais, JP Silva, A Paiva.
Frequency and Functional Activity of Th17, Tc17 and other T cell subsets in Systemic Lupus Erythematosus.
Cell Immunol 2010, 264(1):97-103.
JA Hollenbach, A Meenagh, C Sleator, C Alaez, M Bengoche, A Canossi, G Contreras, L Creary, I Evseeva, C Gorodezky, R-A Hardie, T Hemming Karlsen, B Lie, M Luo, M Martinetti, C Navarette, D CM de Oliveira, G Ozzella, A Pasi, E Pavlova, S Pinto, LC Porto, P Santos, A Slavcev, D Srinak, S Tavoularis, S Tonks, E Trachtenberg, S Vejbaesya & D Middleton.
Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.
Tissue Antigens 2010, 76(1):9-17.
AM Teixeira, P Garrido, P Santos, R Alves R, Parada B, Costa E, Almeida A, Teixeira-Lemos E, Sereno J, Pinto R, Belo L, Santos-Silva A, Teixeira F, Reis F.
Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure.
Ren Fail. 2010;32(9):1073-80.
L Geraldes, J Morgado, A Almeida, A Todo-Bom, P Santos, A Paiva, C Chieira, ML Pais
Different patterns of gene expression of CD4+/CD25++/CD127low Regulatory T-cells HLA-DR+
or HLA-DR- in allergy
J Investig Allergol Clin Immunol. 2010;20(3):201-9.
L Ferreira, E Teixeira de Lemos, AF Pinto, B Parada, R Pinto, P Santos, C Mega, H Vala, Garrido P, Sereno J, Melo A, Teixeira F, Reis F
Sitagliptin treatment corrects the cardiometabolic dysfunction in an animal model of type 2 diabetes (ZDF rat)
Mediators Inflamm 2010 (doi:10.1155/2010/592760)
A Almeida, P Santos, A Cabrita, R Alves
The sex influence in chronic kidney disease. Teachings from a genomic approach to fibrosis in experimental obstructive nephropathy
Port J Nephrol Hypert 2010; 24(3).
M Silva, D Azenha, C Pereira, A Almeida, S Balseiro, AM Sampaio, P Santos, L Carvalho.
Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDNK2A (P16INK4A), PTGS2 (COX2) and EGFR genes through methylation.
Acta Med Port. 2010; 23(1):005-014.
P Garrido, E Costa, E Texeira-Lemos, B Parada, M Teixeira, P Santos, N Piloto, P Sereno, R Alves, R Pinto, P Rocha-Pereira, A Figueiredo, S Nunes, AMP Romão, L Carvalho, P Couceiro, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological, biochemical and cardiovascular characterization of a rat model of moderate chronic kidney disease.
Bol Soc Port Hemorreol Microcir 2010, 25(2): 9-22.
N Piloto, HM Teixeira, P Garrido, E Teixeira-Lemos, M Teixeira, B Parada, J Sereno, R Pinto, R Alves, P Santos, AM Romão, S Nunes, P Neto, L Carvalho, P Couceiro, F Xavier, P Rocha-Pereira, E Costa, L Belo, A Santos-Silva, F Teixeira, F Reis.
Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping.
Bol Soc Port Hemorreol Microcir 2010, 25(1): 11-22.
C Simões, A Almeida, P Santos, A Paiva.
CCR7 e CXCR4 expression and cyclin D1 mRNA expression in mantle cell lymphoma and B cell chronic lymphocytic leukemia.
Rev Port Cienc Biomed 2010; V(5): 10-15.
C Camacho, L Carvalho, L Pereira, E Maia, M J Araújo, R Cortes, P Santos.
MBL in chronic infection by hepatitis B virus: structural and promoter genetic polymorphisms and its correlations with plasmatic levels of oligomeric forms.
Rev Port Cienc Biomed 2010; V(5): 22-27.
L Vicente, AP Rodrigues, AP Galante, E Silva, F Simões, I Marques, H Gonçalves, P Santos
Searching for Cytomegalovirus DNA after leukofiltration of blood transfusion units.
Rev Port Cienc Biomed 2010; V(5): 34-37.
A Almeida, R Alves, P Santos
Experimental models of chronic renal disease by obstruction: functional genomics point of view
Rev Port Cienc Biomed 2009; IV(4): 24-31.
R Leite, R Mareco, C Faustino, P Santos
HLA-B*27: high-resolution molecular information and immunopathology
Rev Port Cienc Biomed 2009; IV(4): 40-44.
AI Duarte, P Santos, CR Oliveira, MS Santos, AC Rego.
Insulinneuroprotection against oxidative stress is mediated by Akt and GSK-3βsignalling pathways and changes in protein expression.
Biochem Biophys Acta - Mol Cell Res 2008; 1793(6):994-1002.
MR Silva, A Sampaio, A Almeida, S Balseiro, P Santos, L Carvalho
Identification of IL1B, IL1RN and TNFA gene polymorphisms in chronic gastritis associated toHelicobacter pylori infection and gastric carcinoma.
GE - J Port Gastroenterol 2008;15:8-15.
A Sampaio, P Santos
Factores genéticos do Helicobacter pylori e do hospedeiro na carcinogenese gástrica
Rev Port Cienc Biomed 2008; III(3): 72-78.